Structural evidence for the radical scavenging mechanism of some aminothiol group of radioprotectants

Vijayan, Kalyani and Vedavathi, BM and Mani, A (1993) Structural evidence for the radical scavenging mechanism of some aminothiol group of radioprotectants. Chemical Sciences, 92 (4 amp;). pp. 457-462.

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Abstract

It is well-known that on exposure to ionising radiation, biological systems incur severe damages affecting their properties and functions. Dale (1942) showed that the13; hazardous effects of radiation on biological systems may be reduced by administering some chemicals prior to exposure. Since then, a large number of such chemicals known as 'radioprotectants' have been identified. With the rapid advances in space technology chemical radioprotection has gained importance and extensive research is being earned out to understand the mechanism of action of chemical radioprotectants. Some of the13; well-known theories of radioprotection involve (i) the method of radical scavenging (ii) formation of mixed disulphide (iii) production of tissue hypoxia (iv) donation of hydrogen atoms (v) binding or chelating to the metal ions in the biological system and (vi) introduction of energy traps. An essential pre-requisite for understanding the mechanism of radioprotection is the study of molecular geometry of the radioprotectants. In this context, we have analysed the structures of a few mdioprotectants belonging to the aminothiol family by single crystal x-ray diffraction methods. The results obtained are critically examined with reference to a particular theory of radioprotection.

Item Type: Article
Uncontrolled Keywords: Radioprotectants;Aminothiols;Crystal structure;Radical scavenging;Interaction.
Subjects: CHEMISTRY AND MATERIALS > Chemistry and Materials (General)
Depositing User: Mr. Ravikumar R
Date Deposited: 13 Oct 2006
Last Modified: 24 May 2010 04:21
URI: http://nal-ir.nal.res.in/id/eprint/3007

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