Drug release characteristics of quercetin-loaded TiO2 nanotubes coated with chitosan

Mohan, L and Anandan, C and Rajendran, N (2016) Drug release characteristics of quercetin-loaded TiO2 nanotubes coated with chitosan. International Journal of Biological Macromolecules, 93. pp. 1633-1638. ISSN 01418130

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Official URL: https://www.sciencedirect.com/science/article/pii/...


TiO2 nanotubes formed by anodic oxidation of Ti-6Al-7Nb were loaded with quercetin (TNTQ) and chitosan was coated on the top of the quercetin (TNTQC) to various thicknesses. Field emission scanning electron microscopy (FESEM), 3D and 2D analyses were used to characterize the samples. The drug release studies of TNTQ and TNTQC were studied in Hanks’ solution for 192 h. The studies showed that the native oxide on the sample is substituted by self assembled nanotube arrays by anodisation. FESEM images of chitosan-loaded TNT samples showed that filling of chitosan takes place in inter-tubular space and pores. Drug release studies revealed that the release of drug into the local environment during that duration was constant. The local concentration of the drug can be controlled and tuned by controlling the thickness of the chitosan (0.6, 1 and 3 μm) to fit into an optimal therapeutic window in order to treat postoperative infections, inflammation and for quick healing with better osseointegration of the titanium implants.

Item Type: Article
Subjects: CHEMISTRY AND MATERIALS > Chemistry and Materials (General)
Depositing User: Mrs SK Pratibha
Date Deposited: 27 Feb 2019 17:09
Last Modified: 27 Feb 2019 17:09
URI: http://nal-ir.nal.res.in/id/eprint/13108

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