Vijayan, Kalyani and Anderson, BF and Hodgkin, DC (1973) Crystal and molecular structure of a synthetic compound related to the Penicillins and Cephalosporins, 3-BenzyS 7-t-Butyl 2,2-DimethyI-8-oxo-4-thia-1-aza-6aH-bicycfo[4.2.0]octane-3b,13; 7a-dicarboxylate. Journal of the Chemical Society . pp. 484-488.
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Abstract
An intermediate obtained by Lowe and Ramsay in the synthesis of a homopenicillin has been shown by X-ray analysis to have a structure including a Beta-lactam ring fused to a thiomorpholine ring carrying 2.2-dimethyl and13; 3-benzyloxycarbonyl substituents. The compound crystallises in the space group P2/c, with Z=4 in the unit13; cell of dimensions Alpha= 19.160, 6= 6.369. c = 19.052 A. Beta= 111.59. The crystal structure was solved from13; diffractometer data by the symbolic addition method and refined to an R value of 5.16% for 2697 independent reflections by iterative block-diagonal least-squares procedures. The central six-membered ring exists in a13; distorted chair form and is oriented at 140.8xB0; to the fused Beta-lactam ring.
| Item Type: | Journal Article |
|---|---|
| Uncontrolled Keywords: | Synthetic compound;Crystal and molecular structure |
| Subjects: | CHEMISTRY AND MATERIALS > Chemistry and Materials (General) |
| Division/Department: | Materials Science Division, Other, Other |
| Depositing User: | Mr. Ravikumar R |
| Date Deposited: | 16 Oct 2006 |
| Last Modified: | 24 May 2010 09:51 |
| URI: | http://nal-ir.nal.res.in/id/eprint/3008 |
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