A novel acid catalysed cyclization - synthesis and X-ray crystal structure analysis of 8-Acetoxy-6-(2,4-Dimethoxy-5 -Bromophenyl)-3-Methyltricyclo(5,2,1,03,8)Decan-2-one

Kasturi, TR and Ramachandra, R and Damodaran, KM and Vijayan, Kalyani (1972) A novel acid catalysed cyclization - synthesis and X-ray crystal structure analysis of 8-Acetoxy-6-(2,4-Dimethoxy-5 -Bromophenyl)-3-Methyltricyclo(5,2,1,03,8)Decan-2-one. Tetrahedron Letters, 50 . pp. 5059-5062.

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    Abstract

    In connection with the total synthesis of heterocyclic steroids, we undertook the synthesis of a B-secosteroid intermediate (I) starting from 2',3,4'-trimethoxy-propiophenone [1]. Examples involving a 'B-seco' approach for the total synthesis of steroids are the synthesis of oestrone [2] and steroids -without ring B [3]. We wish to report in this communication the structure of a novel steroid derivative without ring B by an acid catalysed quot;bis cyclization. Incidentally, this forms a new approach to the synthesis of homobrendane derivatives [4].

    Item Type: Journal Article
    Additional Information: Copyright for this article belongs to Pergamon Press
    Uncontrolled Keywords: Catalysed cyclization;X-ray crystal structure
    Subjects: CHEMISTRY AND MATERIALS > Inorganic, Organic and Physical Chemistry
    Division/Department: Other, Other, Other, Materials Science Division
    Depositing User: Mr. Ravikumar R
    Date Deposited: 16 Oct 2006
    Last Modified: 24 May 2010 09:51
    URI: http://nal-ir.nal.res.in/id/eprint/3004

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